Beilstein J. Org. Chem.2015,11, 701–706, doi:10.3762/bjoc.11.80
which demonstrates that the new carrier provides a venue for the future inhibition of proline-richsequencerecognition by FBP21 during assembly of the spliceosome.
Keywords: FBP21-tWW; isothermal titration calorimetry; multivalent polymers; polyglycerol peptide conjugates; proline-richsequence
recognition; Introduction
Pre-mRNA splicing is an important step in the expression of eukaryotic genes, during which non-coding elements are removed from the pre-mRNA and coding elements are ligated to form a mRNA which can further on be translated into protein. The use of alternative splice sites represents
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Graphical Abstract
Figure 1:
Phage display was used to find an optimized binding partner for FBP21-tWW. A) Schematic representat...